6 PATENT FAMILIES
3 international patent applications for vectors
- Peptide derivatives and use thereof as carriers for molecules in the form of conjugates (Application WO 2010/046588).
- Peptide derivatives, preparation thereof and uses thereof (Application WO 2011/131896).
- Compositions and methods for drug delivery (Application WO 2014/060601).
1 international patent application for a vectorised neuroprotective agent
- Activated neurotensin molecules and the uses thereof (Application WO 2015/107182).
1 international patent application for uses of vectors in cancer imaging and radiotherapy
- Compositions and methods for cancer imaging and radiotherapy (Application WO 2018/138372).
1 international patent applications for new vectors
- Receptor-binding molecules, conjugates thereof and their uses (Application WO2020)
REVIEWS AND SCIENTIFIC PUBLICATIONS
- Acier A, Godard M, Gassiot F, Finetti P, Rubis M, Nowak J, Bertucci F, Iovanna JL, Tomasini R, Lécorché P, Jacquot G, Khrestchatisky M, Temsamani J, Malicet C, Vasseur S, Guillaumond F.
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma
Commun Biol. 2021 Aug
- Varini K, Lécorché P, Sonnette R, Gassiot F, Broc B, Godard M, David M, Faucon A, Abouzid K, Ferracci G, Temsamani J, Khrestchatisky M, Jacquot G.
Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies.
J Control Release. 2019 Oct
- David M, Lécorché P, Masse M, Faucon A, Abouzid K, Gaudin N, Varini K, Gassiot F, Ferracci G, Jacquot G, Vlieghe P, Khrestchatisky M.
Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos.
PLoS One. 2018 Feb
- Molino Y, David M, Varini K, Jabès F, Gaudin N, Fortoul A, Bakloul K, Masse M, Bernard A, Drobecq L, Lécorché P, Temsamani J, Jacquot G, and Khrestchatisky M.
Use of LDL receptor–targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.
The FASEB Journal. 2017 Jan
- Jacquot G, Lécorché P, Malcor JD, Laurencin M, Smirnova M, Varini K, Malicet C, Gassiot F, Faucon A, David M, Gaudin N, Masse M, Ferracci G, Dive V, Cisternino S, Khrestchatisky M.
Optimization and inVivo Validation of Peptide Vectors Targeting the LDL Receptor.
Mol Pharm. 2016 Oct
- Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, Hachet C, Ferracci G, David M, Martiny L, Charpentier E, Khrestchatisky M, Rivera S, Dedieu S, Emonard H.
Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.
PLoS One. 2014 Jul
- Perrot G, Langlois B, Devy J, Jeanne A, Verzeaux L, Almagro S, Sartelet H, Hachet C, Schneider C, Sick E, David M, Khrestchatisky M, Emonard H, Martiny L, Dedieu S.
LRP-1—CD44, a new cell surface complex regulating tumor cell adhesion.
Mol Cell Biol. 2012 Aug
- Malcor JD, Payrot N, David M, Faucon A, Abouzid K, Jacquot G, Floquet N, Debarbieux F, Rougon G, Martinez J, Khrestchatisky M, Vlieghe P, Lisowski V.
Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.
J Med Chem. 2012 Mar
